Protein Details: ATP-sensitive inward rectifier potassium channel 8

Protein ID

ICDB_Pro_0842

Protein Name

ATP-sensitive inward rectifier potassium channel 8

Gene Name

KCNJ8

Organism

Homo sapiens (Human)

Length

424 amino acids

AlphaFoldDB

AF-Q15842-F1-model_v4.pdb

Function

This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised;the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity)

Sequence

MLARKSIIPEEYVLARIAAENLRKPRIRDRLPKARFIAKSGACNLAHKNIREQGRFLQDIFTTLVDLKWRHTLVIFTMSFLCSWLLFAIMWWLVAFAHGDIYAYMEKSGMEKSGLESTVCVTNVRSFTSAFLFSIEVQVTIGFGGRMMTEECPLAITVLILQNIVGLIINAVMLGCIFMKTAQAHRRAETLIFSRHAVIAVRNGKLCFMFRVGDLRKSMIISASVRIQVVKKTTTPEGEVVPIHQLDIPVDNPIESNNIFLVAPLIICHVIDKRSPLYDISATDLANQDLEVIVILEGVVETTGITTQARTSYIAEEIQWGHRFVSIVTEEEGVYSVDYSKFGNTVKVAAPRCSARELDEKPSILIQTLQKSELSHQNSLRKRNSMRRNNSMRRNNSIRRNNSSLMVPKVQFMTPEGNQNTSES

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Cantu Syndrome and Sudden Infant Death Syndrome

Location

Predominantly detected in fetal and adult heart.

DOI ID

10.1006/geno.1995.0018; 10.1101/gr.2596504; 10.1016/s0378-1119(98)00086-9; 10.1016/j.hrthm.2009.12.006; 10.1016/j.hrthm.2010.06.016; 10.1002/humu.22555; 10.1074/jbc.m117.804971; 10.1161/circgenetics.111.960195; 10.1016/j.ejmg.2013.09.009

RefSeq

NP_004973.1; XP_005253415.1; XP_016874772.1; XP_016874773.1